NanoCell Therapeutics Announces Three Strategic Appointments to its Scientific Advisory Board

WAYNE, P.A., and UTRECHT, NETHERLANDS — September 30, 2025 — NanoCell Therapeutics, Inc. (“NanoCell”), a biotechnology company developing a non-viral, DNA-based in vivo gene therapy platform, today announced the appointments of Prof. Zoltán Ivics, PhD, Jens Hasskarl, MD, PhD, and Jake Brenner, MD, PhD, to its Scientific Advisory Board (SAB).

“Drs. Ivics, Hasskarl, and Brenner bring expertise that spans the entire gene therapy development spectrum, from foundational research through commercial success to clinical practice,” said Dr. Maurits Geerlings, CEO and President of NanoCell. “Our team looks forward to working closely with them as we advance NanoCell toward its next milestones.”

Dr. Ivics is a distinguished molecular biologist and gene therapy expert who currently serves as Professor at the Institute for Clinical Immunology, University of Leipzig, and Head of Department for Clinical Gene Transfer at the Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany. His scientific achievements include the molecular reconstruction of the Sleeping Beauty transposon, which earned “Molecule of the Year” recognition in 2009 and has opened new pathways for clinical gene therapy applications. With over 190 peer-reviewed publications, more than 8,000 citations, and 12 patents, Ivics has established himself as a leading authority in the field. He brings extensive leadership experience to the NanoCell board, serving as current president of the German Society of Gene Therapy and as an elected member of both the Academia Europaea and the Hungarian Academy of Sciences.

Dr. Hasskarl is a board-certified hematologist and oncologist and seasoned clinical developer, with a given track record in the cell and gene therapies field in clinical development, regulatory strategy, and manufacturing from first-in-human through phase IV. With over two decades of leadership in hematology, oncology, and cell and gene therapy, he has held senior roles at Priothera, Advesya, Tigen Pharma, Celgene/BMS, and Novartis, enabling the approvals of Kymriah®, Breyanzi® and Abecma®. Hasskarl earned his medical degree summa cum laude from the German Cancer Research Center and Heidelberg University, completed a postdoctoral fellowship at Harvard Medical School, and holds a diploma in health economics. His expertise bridges scientific innovation, strategic planning and operational execution, supporting transformative therapies through pivotal trials and global approvals.

Dr. Brenner is an assistant professor and attending physician at the University of Pennsylvania (Penn) in Medicine and Pharmacology. He earned his MD, PhD, and completed residency at Stanford University. Joining Penn in 2018, he splits his time between 6 weeks annually in the ICU and running a bioengineering lab that develops mRNA and DNA lipid nanoparticles for critical illnesses, including a stroke therapy currently in co-development with a major company.

The strategic additions of Drs. Ivics, Hasskarl, and Brenner strengthen NanoCell’s advisory team as it advances toward clinical development. Dr. Ivics brings pioneering transposon technology expertise and key connections in the European gene therapy community. Dr. Hasskarl’s clinical development and regulatory experience at major pharmaceutical companies will help navigate complex approval pathways. Dr. Brenner’s dual role as attending physician and researcher provides crucial patient-centered insights for treatment development.

NanoCell would also like to acknowledge Perry Hackett, PhD, for his contributions and guidance as an SAB member over the years.

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. The company is dedicated to pioneering transformative in-vivo cell engineering through its non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases.

Contact:

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ICR Healthcare

Elizabeth Coleman
Account Supervisor
Phone: 203-682-4783
Email: elizabeth.coleman@icrhealthcare.com

NanoCell Therapeutics Wins EU Funding for Breakthrough CAR-T Cancer Therapy Development

~ Company top-ranked among 120+ submissions for QUIET-CAR project targeting cancer and autoimmune disease

WAYNE, P.A., and UTRECHT, NETHERLANDS — August 14, 2025 — NanoCell Therapeutics, Inc. (“NanoCell”), a biotechnology company developing a non-viral, DNA-based in vivo gene therapy platform, today announced it has been awarded a Eurostars Grant from the European Union (EU) through the Horizon Europe program and the Eureka Network. The grant will fund NanoCell’s QUIET-CAR project, which is focused on the development of targeted lipid nanoparticles containing novel immune-quiet DNA constructs for in vivo CAR-T therapy.

“This funding validates our innovative approach to non-viral gene therapy and will accelerate our QUIET-CAR project toward delivering safer, more accessible CAR-T treatments for patients with cancer and autoimmune disease,” said Dr. Maurits Geerlings, CEO and President of NanoCell Therapeutics. “Being selected and top ranked among over 120 submissions in Europe’s most competitive SME funding program demonstrates the transformative potential of our technology platform.”

The QUIET-CAR project is a collaboration between NanoCell and CPTx, a biotech company developing advanced medicine using AI-supported molecular design and programmable single-stranded DNA fabrication supported by gxstrands. Eurostars, part of the European Partnership on Innovative SMEs and supported by Horizon Europe, is a premier funding initiative designed to accelerate transnational innovation. With participation from 37 countries, the program rigorously selects only the most promising technological breakthroughs, evaluated by independent experts.

NanoCell acknowledges the support of Amsterdam-based Catalyze for the successful preparation of this grant.

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. The company is dedicated to pioneering transformative in-vivo cell engineering through its non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases.

Contact:

Media:
ICR Healthcare
Elizabeth Coleman
Account Supervisor
Phone: 203-682-4783
Email: elizabeth.coleman@icrhealthcare.com

 

NanoCell Announces Publication of Research Data in Journal for ImmunoTherapy of Cancer Demonstrating First-in-Class Non-Viral DNA-Based In Vivo CAR-T Generation

~ Study shows potential of NanoCell Therapeutics’ NCtx platform, and durable CAR-T therapy without ex vivo manufacturing
~ First indication of stable, functional CAR-T cell generation in vivo using targeted lipid nanoparticles for DNA delivery

WAYNE, PA., and UTRECHT, NETHERLANDS — July 29, 2025 — NanoCell Therapeutics, Inc. (“NanoCell”), a biotechnology company developing a non-viral, DNA-based in vivo gene therapy platform, today announced the publication of research data in the  Journal for ImmunoTherapy of Cancer demonstrating its novel targeted lipid nanoparticle delivery system, termed NCtx. This technology enables the direct in vivo generation of chimeric antigen receptor T-cells (CAR-T), potentially transforming the accessibility and scalability of CAR-T therapies for cancer patients worldwide.

The study, titled “T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles,” represents the first successful demonstration of efficient non-viral DNA delivery to T cells in vivo, positioning NCtx as a promising advancement in the field of in vivo CAR-T therapy.

While CAR-T therapy has shown remarkable success in treating hematologic malignancies, current approaches face significant barriers including high manufacturing costs (approximately $300,000 per patient), complex logistics, lengthy manufacturing times, and limited patient access due to specialized facility requirements. The NCtx platform co-delivers minicircle DNA encoding a CAR construct and transposase mRNA in a single targeted nanoparticle, enabling stable genomic integration and durable CAR expression. The system utilizes dual CD7/CD3 targeting to achieve T cell specificity while activating cells for enhanced DNA uptake.

Researchers demonstrated that a single intravenous dose of NCtx led to robust CAR-T cell generation in multiple humanized mouse models, effective tumor control and significantly extended survival, durable CAR expression and functional anti-tumor activity at doses as low as 4 µg/kg.

“This research demonstrates a new path forward for CAR-T therapy,” said Dr. Jacek Lubelski, senior author and CTO at NanoCell Therapeutics. “By enabling in vivo CAR-T generation through a single, targeted nanoparticle injection, we can potentially dramatically simplify treatment protocols while expanding access in the future to patients worldwide who currently cannot benefit from conventional CAR-T therapies.”

Results were generated using a dual-CAR construct targeting CD19 and CD22, developed by Shanghai Cell Therapy Group (SHCell) https://www.shcell.com/.

“Our collaboration with SHCell underscores the power of combining innovative delivery platforms with cutting-edge CAR designs,” said Dr. Maurits Geerlings, CEO and President of NanoCell Therapeutics. “We are excited about the potential of this partnership to accelerate the development of transformative therapies for patients with B cell cancers and beyond.”

The platform’s modular design enables rapid adaptation for multiple therapeutic targets across oncology and autoimmune diseases. The study was conducted by research teams at NanoCell Therapeutics and the University Medical Centre Utrecht, with support from the European Union’s Horizon Europe and Horizon 2020 research programs.

As NanoCell continues to advance its NCtx platform, the company is expected to pursue an IMPD application pending financing, marking a critical step toward clinical development.

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. The company is dedicated to pioneering transformative in-vivo cell engineering through its non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases.

Contact:

Media:
ICR Healthcare
Elizabeth Coleman
Account Supervisor
Phone: 203-682-4783
Email: elizabeth.coleman@icrhealthcare.com

NanoCell Secures Seed-Extension Financing from The Institute for Follicular Lymphoma Innovation to Advance Lead Clinical Candidate for B Cell Malignancies

WAYNE, P.A., and UTRECHT, NETHERLANDS — June 16, 2025 — NanoCell Therapeutics, Inc. (“NanoCell”), a biotechnology company developing a non-viral, DNA-based in vivo gene therapy platform, today announced the successful closing of a seed-extension financing round, with participation from The Institute for Follicular Lymphoma Innovation (“IFLI”), a leading non-profit organization dedicated exclusively to funding innovative follicular lymphoma research and development.

The funding will accelerate IND-enabling development of NanoCell’s lead clinical candidate, NCTX-01, a dual-CAR CD19/CD22 in vivo CAR-T therapy for B cell malignancies. NanoCell will use the capital to further evaluate NCTX-01’s safety, efficacy and durability in treating aggressive forms of lymphoma, including diffuse large B-cell lymphoma and follicular lymphoma.

“IFLI’s support enables us to accelerate NCTX-01 through preclinical development to clinical development,” said Maurits Geerlings, MD, President & Chief Executive Officer of NanoCell. “This partnership provides crucial resources to generate the preclinical data package needed for regulatory discussions. IFLI shares our belief that non-viral in vivo approaches have transformative potential to address significant unmet medical needs for patients who currently have limited treatment options.

“NanoCell’s innovative platform offers a novel approach to treating both follicular lymphoma and diffuse large B-cell lymphoma and could potentially overcome many of the current barriers that limit patient access to CAR-T therapies,” said Michel Azoulay, MD, MBA, Chief Medical Officer at IFLI. “Supporting this program aligns with IFLI’s mission to accelerate innovative therapies that can make a meaningful difference in the lives of patients.”

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. The company is dedicated to pioneering transformative in-vivo cell engineering through its non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases. By leveraging a proprietary targeted lipid nanoparticle delivery platform, NanoCell is addressing key limitations of traditional CAR-T therapies, including high manufacturing costs, complex logistics and limited accessibility. The company’s approach aims to deliver one-time, off-the-shelf treatments for cancer and autoimmune diseases, with the potential to reach broader patient populations.

About the Institute for Follicular Lymphoma Innovation (IFLI)

The Institute for Follicular Lymphoma Innovation (IFLI) is a global, non-profit, private foundation dedicated to accelerating the development of innovative treatment options for patients with follicular lymphoma (FL). IFLI supports cutting-edge research and technology to lead to the development and commercialization of novel therapeutics and/or biomarkers for the treatment of FL, and to understand the biology of FL. The foundation deploys its budget across grants, project-based partnerships, and venture philanthropic investments to achieve its innovation goals. IFLI promotes collaboration and works to enable data sharing and the exchange of knowledge and expertise among researchers and institutions advancing FL research and for more information on IFLI, visit www.i-fli.org.

Contact:

Media:
ICR Healthcare
Elizabeth Coleman
Account Supervisor
Phone: 203-682-4783
Email: elizabeth.coleman@icrhealthcare.com

NanoCell Therapeutics Announces Upcoming Participation in Investor Conferences

WAYNE and UTRECHT – Feb. 4, 2025 — NanoCell Therapeutics, Inc. (“NanoCell”), a company developing a non-viral, DNA-based in vivo gene therapy platform, today announced that its CEO, Dr. Maurits Geerlings, will attend two upcoming investor conferences: BIO CEO & Investor Conference in New York City (Feb 10-11, 2025) and BIO-Europe Spring in Milan (March 17-19, 2025).

During these events, Dr. Geerlings will provide insights into NanoCell’s latest progress, including advancements in NCTX-1, its dual-CAR CD19/CD22 in vivo CAR-T therapy for B cell malignancies, as well as opportunities for strategic partnerships and investment. One-on-one meetings will be held to discuss NanoCell’s pioneering approach to in-vivo CAR-T cell generation using targeted lipid nanoparticles (tLNPs) and the company’s broader vision for revolutionizing adoptive cell therapy.

Conference Details:

BIO CEO & Investor Conference
Date: February 10–11, 2025
Location: New York, NY
Format: 1×1 Meetings

BIO-Europe Spring
Date: March 17–19, 2025
Location: Milan, Italy
Format: 1×1 Meetings

To learn more about our work and stay updated about our latest developments, please visit our website at http://www.nanocelltx.com.

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. We are dedicated to pioneering transformative in-vivo cell engineering through our non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases.