Author: pconington

• Proof-of-concept for in vivo CAR-T generation using non-viral vectors delivering stably integrating DNA
• Durable CAR expression and tumor control in human PBMC engrafted mouse model of B-cell leukemia

WAYNE and UTRECHT – Nov. 8, 2024 — NanoCell Therapeutics, Inc. (“NanoCell”), a company developing a non-viral, DNA-based in vivo gene therapy platform, today announced animal proof of concept  data from its lead program utilizing targeted lipid nanoparticle (tLNP) technology for in vivo CAR-T cell generation.

“The studies demonstrated successful targeting and stable CAR expression in a human PBMC engrafted mouse model evaluating the company’s tLNP technology. These findings were initially shared at the 31st Annual Congress of the European Society of Gene & Cell Therapy (ESGCT) in Rome last month. Additional data are being presented at the SITC 39th Annual Meeting in Houston (Abstract #284)]”

These preclinical data demonstrate the potential of our cell-directed, lipid-enabled delivery platform,” said Maurits Geerlings, CEO of NanoCell. “As we progress from platform validation, we are advancing our lead clinical construct, a dual-CAR CD19/CD22 targeting B cell malignancies and autoimmune diseases.”

“Our proof of concept studies demonstrate that our cell-directed, lipid-enabled delivery system can achieve stable CAR expression in T cells in vivo,” said Dr. Jacek Lubelski, Chief Technology Officer of NanoCell. “These results prove the mechanism of action for our non-viral vector technology approach.”

Click here to view Abstract #284

To learn more about our work and stay updated about our latest developments, please visit our website at http://www.nanocelltx.com.

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. We are dedicated to pioneering transformative in-vivo cell engineering through our non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases. NanoCell’s advanced technology platform aims to evolve and enhance traditional adoptive cell therapy methods into advanced in-vivo treatments. Our objective is to streamline the overall treatment process, bolstering patient access, potential clinical benefits, and cost-effective manufacturing. For more information, visit: http://www.nanocelltx.com.

NanoCell Therapeutics Inc. | Investor Relations
T: +31 (0) 70 3643095 | E: contact@nanocelltx.com

WAYNE and UTRECHT – Oct. 22, 2024 — NanoCell Therapeutics, Inc. (“NanoCell”), a company developing in-vivo cell engineering solutions based on its proprietary non-viral, DNA-based gene therapy platform, today announced that the team will present at several upcoming investor and scientific conferences.

Initial data from the company’s ongoing preclinical studies on targeted lipid nanoparticle (tLNP) technology for in vivo CAR-T cell generation will be presented at the ESGCT by Dr. Jacek Lubelski, NanoCell’s Chief Technology Officer. The presentation will highlight preclinical results demonstrating the ability of the company’s novel tLNP technology to generate persistent CAR-T cells in vivo, showing tumor control and extended survival in a human PBMC engrafted mouse model of B-cell leukemia.

At the SITC 39th Annual Meeting and the SITC Immune Engineering Workshop in Houston, Texas, Dr. Lubelski will present new data from the company’s non-viral vector platform research program.

NanoCell will participate in two upcoming investor conferences. Dr. Maurits Geerlings, CEO, will join a panel discussion and host investor meetings at the Longwood Healthcare Leaders Boston CEO Forum (October 28-29, 2024), followed by one-on-one investor meetings at BioEurope in Stockholm (November 4-6, 2024).

Presentation Details:

European Society of Gene & Cell Therapy (ESGCT):
Oral Presentation: “tLNPs can effectively deliver DNA to T-cells and generate long-acting CAR-T cells in vivo”
Number: OR050
Session: Parallel Session 6c: Non Viral Vectors / Nanotechnology I
Location: Meeting Room 2
Timing: Wednesday, October 23rd, 2024,
Timing: 17:30-19:30 

Presentation Details:

Society for Immunotherapy of Cancer (SITC) 39th Annual Meeting:
Poster Presentation
Title: “Efficient generation of long-lasting CAR-T cells in vivo using novel non-viral vector”
Abstract Number: 284
Timing: November 8-10, 2024
Location: Houston, TX

Additional Poster Abstract Presentation:

SITC Immune Engineering Workshop:
Titel: “Efficient generation of long-lasting CAR-T cells in vivo using novel non-viral vector”
Timing: November 7, 2024
Location: Houston, TX

Investor Conferences

Event Details:
Longwood Healthcare Leaders Boston CEO Forum
Investor 1:1 Meetings and Panel
Title: Innovation in Cell Therapy
Timing: October 28-29, 2024
Venue: Mandarin Oriental Boston, 776 Boylston Street, Boston, MA, USA 

Event Details:
BioEurope
Investor 1:1 Meetings
Company Overview
Timing: November 4–6, 2024
Venue: Stockholmsmässan, Mässvägen 1, 125 30 Älvsjö, Stockholm, Sweden

To learn more about our work and stay updated about our latest developments, please visit our website at http://www.nanocelltx.com.

 

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. We are dedicated to pioneering transformative in-vivo cell engineering through our non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases. NanoCell’s advanced technology platform aims to evolve and enhance traditional adoptive cell therapy methods into advanced in-vivo treatments. Our objective is to streamline the overall treatment process, bolstering patient access, potential clinical benefits, and cost-effective manufacturing. For more information, visit: http://www.nanocelltx.com.

NanoCell Therapeutics Inc. | Investor Relations
T: +31 (0) 70 3643095 | E: contact@nanocelltx.com

• OneChain’s CD22 CAR technology and NanoCell’s non-viral, DNA-based in vivo CAR-T platform will be utilized to develop innovative treatment options.

PA, USA Wayne and Barcelona, Spain,  – May 16 2024, —  OneChain Immunotherapeutics S.L. (OneChain) and NanoCell Therapeutics Inc. (NanoCell), announced today a strategic collaboration to develop a novel in vivo CAR-T therapy targeting B-cell lymphomas. This partnership combines OneChain’s advanced CD22 CAR technology with NanoCell’s innovative in vivo CAR-T technology platform, opening a new course for treatment in this disease area with persisting unmet need.

NanoCell’s non-viral, DNA-based CAR-T technology platform has demonstrated compelling results in pre-clinical proof of concept studies, durable CAR-T expression and robust tumor control. This new approach offers a viable alternative to conventional viral methods, potentially establishing a new standard in the field.

OneChain’s proprietary CD22 CAR molecule was developed and optimized by Professor Pablo Menendez, founder of OneChain and Professor at the Josep Carreras Institute for Leukemia. Preclinical validation of this CD22 CAR has been published in multiple peer-reviewed academic journals¹.

“Partnering with NanoCell allows us to integrate our CD22 CAR with their innovative in vivo CAR-T technology, aiming to enhance treatment options for B-cell lymphoma”, said Stefanos Theoharis, CEO of OneChain Immunotherapeutics.

“We look forward to collaborating with OneChain Immunotherapeutics, and potentially offering innovative treatments beyond traditional CD19 therapies for patients with B-cell malignancies”, added Maurts Geerlings, CEO of NanoCell Therapeutics.

To learn more about our work and stay updated about our latest developments, please visit our websites at https://www.onechaintx.com/ and http://www.nanocelltx.com.

About OneChain Immunotherapeutics

OneChain Immunotherapeutics was founded in June 2020 by the Josep Carreras Leukaemia Research Institute, ICREA, and Dr. Pablo Menéndez. It is currently supported by a group of partners including the Josep Carreras Leukemia Foundation, venture capital entities Invivo Partners, Nara Capital, and Clave Capital, and the Center for Technological Development and Innovation (CDTI). The company, with headquarters at the Barcelona Science Park, focuses on developing treatments based on immunotherapy for malignant neoplasms. More information: https://www.onechaintx.com/

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. We are dedicated to pioneering transformative in-vivo cell engineering through our non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases. NanoCell’s advanced technology platform aims to evolve and enhance traditional adoptive cell therapy methods into advanced in-vivo treatments. Our objective is to streamline the overall treatment process, bolstering patient access, potential clinical benefits, and cost-effective manufacturing.

OneChain Immunotherapeutics S.L. | Communication and press office
Telephone | +34 913766458
E: press@scienseed.com 

NanoCell Therapeutics Inc. | Investor Relations & Media
T: +31 (0) 70 3643095  |  E: contact@nanocelltx.com

¹Velasco- Hernandez T, Zanetti SR, Roca- Ho H, et al. Efficient elimination of primary B- ALL cells in vitro and in vivo using a novel 4- 1BB- based CAR targeting a membrane-distal CD22 epitope. Journal for ImmunoTherapy of Cancer 2020;8:e000896. doi: 10.1136/jitc-2020-000896.

Wayne, PA – March 19, 2024 — NanoCell Therapeutics, Inc. (“NanoCell”), a company developing in-vivo cell engineering solutions based on its proprietary non-viral, DNA-based gene therapy platform, today announced the appointment of Charles F. Albright, Ph.D., to its Scientific Advisory Board.

“We’re honored to welcome Charles, a globally recognized scientist with a distinguished career in biotechnology and pharmaceuticals, to NanoCell’s Scientific Advisory Board,” said Maurits Geerlings, NanoCell’s Chief Executive Officer. “Charles is contributing to the scientific diversity of our board with his deep expertise in gene editing, gene delivery and drug discovery. He will bring significant value as we are expanding our pipeline in oncology and autoimmune diseases through our innovative in-vivo cell engineering platform.”

Dr. Albright is the Chief Scientific Officer at Affinia Therapeutics, leading the creation of innovative AAV vectors for gene therapy. Previously, as Executive Vice President and Chief Scientific Officer at Editas Medicine, he played a pivotal role in pioneering CRISPR gene editing therapies, following his position as Vice President at Bristol-Myers Squibb Company, focusing on Genetically Defined Diseases and Genomics. Dr. Albright’s contributions include advancing genetic disease and cancer treatments, notably his work on the first IND for in vivo CRISPR/Cas9 editing.

“NanoCell’s in-vivo gene therapy platform is a versatile non-viral, DNA based technology targeting cancer and autoimmune diseases by enabling direct, in-body cell engineering,” said Dr. Charles. “I am pleased to join the Company at this exciting stage as a member of the Scientific Advisory Board and help advance this innovative technology to make a difference in the lives of people impacted by cancer and other serious diseases.”

 

About NanoCell Therapeutics, Inc.

NanoCell Therapeutics is a privately held, transatlantic biotechnology company with locations in Wayne, Pennsylvania, and Utrecht, the Netherlands. We are dedicated to pioneering transformative in-vivo cell engineering through our non-viral, DNA-based gene therapy platform, primarily targeting oncology and autoimmune diseases. NanoCell’s advanced technology platform aims to evolve and enhance traditional adoptive cell therapy methods into advanced in-vivo treatments. Our objective is to streamline the overall treatment process, bolstering patient access, potential clinical benefits, and cost-effective manufacturing. For more information, visit: http://www.nanocelltx.com.

NanoCell Therapeutics Inc. | Investor Relations
T: +31 (0) 70 3643095 | E: contact@nanocelltx.com